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KMID : 1035620150030050365
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Allergy Asthma & Respiratory Disease
2015 Volume.3 No. 5 p.365 ~ p.369
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Opportunistic lung infections as a manifestation of Good's syndrome
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김숙연:Kim Suk-Yeon
김주희:Kim Joo-Hee/황하원:Hwang Ha-Won/김광윤:Kim Kwang-Youn/박성훈:Park Sung-Hoon/황영일:Hwang Young-Il/장성훈:Jang Seung-Hun/정기석:Jung Ki-Suck
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Abstract
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Good's syndrome is an acquired immunodeficiency state associated with thymoma. It is characterized by recurrent infection, autoimmune disease, and immunologic abnormality. The insufficient immunity can be managed by intravenous immunoglobulin (IVIG) replacement therapy. We describe 2 patients who presented with Pneumocystis jiroveci pneumonia and Cytomegalovirus pneumonia after thymectomy for a thymoma. Immunologic study revealed hypogammaglobulinemia with very low B-cell count, consistent with Good's syndrome. They were successfully treated with trimethoprim/sulfamethoxazole and gancyclovir respectively, and they are all well without additional infections, receiving regular IVIG replacement.
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KEYWORD
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Good's syndrome, Thymoma, Hypogammaglobulinemia, Pneumonia, Opportunistic infections
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